Making Phase 2 clinical trials affordable

NickOttens

We have found several ways in which the cost of Phase 2 clinical trials might be reduced:

• Allowing only supplements, over-the-counter and repurposed drugs, or SORDs.
• Reducing the number of participants in each cohort (30-50 at most).
• Restricting patients' age to 70+ years old, so that the intervention's impact is more pronounced and significant even with a small cohort.
• Optimizing the trial duration (3-12 months).
• Utilizing a shared control group. (Teams would not directly communicate with their cohorts).
• Making use of the XPRIZE brand to recruit volunteers.
• Focusing only on measuring biomarkers that are directly relevant to the competition and end goal, thereby minimizing testing costs.

What are your thoughts on each of these potential cost-saving options? Can you recommend others?

NickOttens

@grahampawelec, @taboma, @anttipe, @DGlass, can I ask for your input on this question?

The cost of a Phase 2 clinical trial can be prohibitive. In order to make sure that not only established firms can compete in an XPRIZE Age Reversal, we're looking for ways to brings costs down.

What are your thoughts on our ideas? Would you add anything to the list?

NickOttens

@Longevity_Analytics, @eli, and @walticular, you might have insight on this question for us as well. How could we reduce the costs of Phase 2 clinical trials for an XPRIZE?

NickOttens

@ddotdan, @YuriDeigin, @HarishHandral, @ahessel, please let us know if you have suggestions for making Phase 2 clinical trials more affordable for an XPRIZE.

We're considering allowing competitor-teams to only test supplements, over-the-counter and repurposed drugs, optimizing the trial duration as well as the number of participants, and utilizing a shared control group.

Are there other cost-saving options?