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Safety of rejuvenating the immune system

How safe is it to attempt to rejuvenate the immune system?
How can we minimize the risk of adverse events, or of dangerous side-effects (both acute and chronic ones, such as increasing the risk for developing autoimmune diseases)?
How can we minimize the risk of adverse events, or of dangerous side-effects (both acute and chronic ones, such as increasing the risk for developing autoimmune diseases)?
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Also see: How lifestyle and lifestyle diseases affect the aging process
We're thinking about focusing an age-reversal XPRIZE on rejuvenating immune system. Would that be safe? What are the risks?